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Synthesis 1988; 1988(9): 683-685
DOI: 10.1055/s-1988-27670
DOI: 10.1055/s-1988-27670
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data processing and storage.Synthesis and Reactions of Isoquinoline Derivatives III.1 Synthesis and Reactions of 3,4-Dihalogeno-1-phenylisoquinolines
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Publication Date:
18 September 2002 (online)
Reaction of 1-phenyl-1,4-dihydro-3(2H)isoquinolinone (1) with phosphorus pentahalides as well as a two-step procedure involving a Vilsmeier-Haack acylation of 1 followed by oxidative cleavage with sodium hypohalites make 3,4-dihalogeno-1-phenylisoquinolines easily available.